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Ultrabrain (250 hylki)

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Framleiðandi: Energy Blueprint Labs

Innihaldslýsing:

RHODIOLA ROSEA

  • Stabilizes mood
  • Reduces anxiety and depression
  • Improves cognitive performance
  • Reduces feelings of exhaustion, irritability, and burnout
  • Increases resilience (resistance to stress)
  • Functions as an antioxidant and anti-inflammatory
  • Fast-acting

In first-year medical student, taking rhodiola rosea for 3 weeks before exams improved mental performance by 50% and reduced mental fatigue by 42%.1

A large study of over 100 adults with chronic work and life-related stress found that 400 mg/d of rhodiola rosea significantly reduced feelings of exhaustion, irritability, and anxiety in as little as three days!2

In adults with chronic fatigue syndrome, 400 mg per day of rhodiola improved every aspect of fatigue after just 1 week, with further improvements seen after 8 weeks.3

Ultimately, 83% of the participants reported “very much” or “much” improved conditions with every aspect of fatigue, stress, and global impairment being cut in half.

LION'S MANE POWDER

  • Reduces anxiety and depression
  • Helps improve memory, concentration, and overall cognitive function
  • Promotes nerve growth and regeneration in the brain
  • Reduces inflammation
  • Stabilizes mood
  • Restores key neurotransmitters
Research has found that 1,500 mg per day for 8 weeks reduced feelings of anxiety by 27% and feelings of depression by 39%.4

ALPHA-GPC

  • Protects neurons in the brain and supports neurotransmission
  • Increases dopamine and serotonin signaling in the brain
  • Decreases risk of vascular dementia
  • More effective than Alzheimer drug (Aricept) at improving cognition
The choline supplied by alpha-GPC plays a critical role in neuronal plasticity, membrane stability, signaling events, and neurotransmission.5 Choline is, without a doubt, neuroprotective, and a low brain concentration is one of the primary causes of vascular dementia (loss of memory and ability to think). 6,7 As of 2007, alpha-GPC has been investigated in 14 clinical trials enrolling individuals with neurodegenerative disorders, vascular dementia, or stroke, and the results have been very positive. For example, compared to drug therapy for Alzheimer’s disease (the cholinesterase inhibitor called donepezil or Aricept), alpha-GPC was more effective at improving cognition over 6 months. 8  

CHOLINE

  • Promotes the health of cell membranes
  • Improves memory and overall brain cognition
  • Improves motor function
  • Increases focus and reduces impulsive behavior
  • Improves neuroplasticity (helps the brain adapt to new situations)

Unlike alpha-GPC, however, Choline is the direct precursor for the synthesis of phosphatidylcholine, one of the most abundant and important structural components of cell membranes. 9 Research in humans has suggested that taking Choline increases phosphatidylcholine synthesis within the brain.10 Indeed, 6 weeks of daily supplementation with 500 mg of Choline increases brain phospholipid concentrations. A Cochrane Systematic Review of 14 double-blind, placebo-controlled trials of older adults with cognitive deficits like dementia reported that Choline was able to improve memory, correct abnormal behaviors, and increase the global impression that physicians have towards the participants. 11

BACOPA

  • Enhances short-term and long-term memory
  • Enhances learning, visual processing, cognitive performance
  • Improves mood and reduces depression and anxiety
  • Reduces oxidative stress
  • Neuroprotective
  • Reduces β-amyloid deposits
  • Enhances communication between neurons
  • Increases blood flow
In healthy elderly adults (average 73 years), 300 mg/d of bacopa (50% bacosides) for 12 weeks significantly improved multiple measures of cognitive performance and mood state compared to placebo, including memory, reaction time, depression, and anxiety compared to placebo 12 In young medical students, 300 mg/d of bacopa (50% bacosides) for 6 weeks significantly improved efficiency of attention, freedom from distractibility, and working memory. 13 In healthy adults, 300 mg/d of bacopa (50% bacosides) for 12 weeks significantly improved speed of visual information processing, learning rate, memory consolidation, and decreased anxiety compared to placebo. 14

GINKGO BILOBA

  • Neuroprotective
  • Improves memory and cognitive performance
  • Works as an antioxidant
  • Counteracts cognitive impairment
  • Improves neuroplasticity
  • Preserves brain receptors in aging adults
Ginkgo biloba possesses an array of activities relevant to brain health and neurological function. Numerous studies show that it is neuroprotective, an antioxidant, preserves brain receptors susceptible to age-related loss, counteracts cognitive impairment, and enhances neuronal plasticity, and improves memory.15 A systematic review of 12 meta-analyses found that ginkgo Biloba improves cognitive performance, activities of daily living, and clinical global impression in the treatment of dementia at doses greater than 200mg/day (usually 240mg/day) administered for at least 22 weeks (5 months). 16

COFFEE FRUIT (NEUROFACTOR)

  • Increases Brain-Derived Neurotrophic Factor (BDNF)
  • Powerful antioxidant
  • Improves neuroplasticity
  • Helps to  grow new neurons and prevent neurodegeneration
  • Improves long-term memory
NeuroFactor is a patented extract of the whole coffee fruit, including both the fruiting body and the coffee bean it contains. While many are familiar with the coffee bean and the joy it brings through brewing into a morning cup of Joe, the fruit contains powerful antioxidant compounds that benefit our brain and body17,18 Clinical studies in healthy adults have shown that 100 mg of NeuroFactor nearly doubles concentrations of brain-derived neurotrophic factor (BDNF) after 1–2 hours,19,20 beating out other forms of coffee bioactives, caffeine, and the phytochemical-rich grape seed extract. BDNF is a key protein involved in brain health, well established to be critical for neuroplasticity (helps the brain adapt to new situations), 21 neurogenesis (the growth, regeneration and creation of new neurons and synapses),22,23 long-term memory, 24 prevention of neurodegeneration.25  

HUPERZINE A

  • Promotes learning
  • Used for centuries to treat brain-based illnesses
  • Improves cognition, especially in people with Alzheimer’s and vascular dementia
  • Naturally occurring acetylcholinesterase inhibitor (primary class of drugs for treating Alzheimer’s and dementia)
Huperzine-A is an alkaloid derived from the moss Huperzia serrata, which itself has been used in traditional Chinese Medicine for centuries. It’s a naturally occurring acetylcholinesterase inhibitor, which represents the primary class of drugs for treating Alzheimer’s dementia, and functions to inhibit the enzyme that degrades acetylcholine, the neurotransmitter responsible for learning new information. 26 At least 20 randomized controlled trials have evaluated the efficacy of huperzine A in patients with Alzheimer’s disease, with a meta-analysis showing improvements for cognitive function, daily living activity, and global clinical assessments over 8–36 weeks.27 Other meta-analyses have reported that huperzine A improves cognition in those with vascular dementia, 28 as well as in those with major depression. 29

ACETYL-L CARNITINE

  • Improves brain function, especially memory and attention
  • Reduces oxidative stress
  • Protects against β-amyloid neurotoxicity
  • Reduces mental and physical fatigue
  • Reduces depression – more effective than antidepressant drugs! (And with far fewer side effects)
  • Reduces pain and increases nerve conduction
  • Prevents progression of brain-related disease
Carnitine is an essential component of mitochondria, responsible for shuttling fatty acids across the mitochondrial membranes so that they can be used for energy production. Acetyl L-Carnitine (ALCAR) is a unique form of L-Carnitine that has incredible brain- and body-boosting properties. Why? Because supplementation is well-established to increase mitochondrial function and energy production,30,31 particularly within the brain thanks to ALCAR’s ability to easily cross the blood-brain barrier.32,33,34,35,36 It also protects against β-amlyoid neurotoxicity and reduces oxidative stress. 37 Notably, ALCAR concentrations slowly decline as cognitive impairment progresses, ultimately being 36% lower in Alzheimer’s patients than healthy adults. 38 In elderly adults suffering from excessive fatigue, ALCAR supplementation improved cognitive function, reduced mental and physical fatigue, and improved the ability to function in daily life.39 A meta-analysis of 21 randomized controlled trials involving patients with mild cognitive impairment or Alzheimer’s disease found that ALCAR significantly improved cognitive function and prevented the progression of Alzheimer’s after as little as 3 months! 40 A meta-analysis of 12 randomized controlled trials found ALCAR to significantly reduce depressive symptoms with an efficacy similar to antidepressant drugs, but with far less side effects. 41

TRIMETHYLGLYCINE

  • Reduces oxidative stress and inflammation
  • Enhances proper protein synthesis
  • Improves cognitive function, especially memory
  • Reduces depression
One of the principal benefits of TMG supplementation is its ability to reduce homocysteine concentrations, 42,43 which reduces exposure to oxidative stress and inflammation. 44,45 TMG levels in the body have been linked to better cognitive function, particularly memory and executive function,46 and the hippocampus of the brain selectively accumulates betaine.47 Additionally, TMG’s methylation abilities may hold effectiveness for reducing depression when paired with SAMe, 48,49 potentially being equivalent to antidepressant drugs but with less side effects. 50

SAFFRON EXTRACT

  • As effective as prescription drugs (with less side effects) in:
  • Reducing depression Treating obsessive compulsive disorder (OCD)
  • Improving cognitive function
  • Antioxidant and anti-inflammatory
  • Neuroprotective
Saffron is one of the most well-researched antidepressant compounds available, with three separate meta-analyses of randomized controlled trials indicating that 30 mg/d has a potency comparable to prescription drugs but with less side effects. 51,52,53

URIDINE MONOPHOSPHATE

  • art of nucleic acids in DNA and RNA
  • Critical for creation of brain phospholipids
  • Induces nerve growth
  • Increases learning
  • Improves depression

Uridine is one of the five standard nucleosides that make up the nucleic acids of genetic material (DNA and RNA). It is known to pass the blood-brain barrier, 59 and is involved in several neurologically critical functions, like synthesis of synthesis of brain phospholipids, 60 the formation of brain synapses that are required for learning and communications,61,62 and inducing nerve growth and differentiation. 63,64 In depressed adolescents with bipolar disorder, uridine supplementation for six weeks reduced depression by 58%. 65

GABA

  • Critical for relaxation and stress management
  • Strong emotional regulator
  • Improves memory, focus, and attention
  • Increases empathy
  • Improves resiliency
  • Decreases depression and anxiety
GABA is the most potent inhibitory neurotransmitter in human brains. It regulates many of the sedative actions in brain tissue and is critical for relaxation. 66,67 It is also critical for the regulation of neuronal communication, cognition, emotion, and memory. 68,69,70 It’s been suggested that higher GABA levels help reduce distraction in the brain, which makes it possible to react and make decisions more quickly. 71 A single dose of 800 mg of GABA has been shown to improve attention and task switching in healthy young adults. 72,73 It has also been shown to potently combat anxiety.

AGMATINE SULFATE

  • Important neurotransmitter
  • Improves learning and memory
  • Reduces anxiety and depression
  • Protects neurons and enhances cell growth
  • Protects mitochondria
  • More effective at relieving pain than conventional medications
Clinical research has demonstrated agmatine’s pain-relieving properties. In a randomized, double-blind, placebo-controlled study of individuals with back pain from herniated lumbar discs, agmatine sulfate supplementation for two weeks reduced pain by 25–28% and improved parameters of general health by 65–76%. 74 Moreover, these benefits persisted for 2 months after supplementation ended. In a pilot study of two men and one woman with clinical depression and currently in the grip of a major depressive disorder episode, supplementing agmatine for 3–4 weeks “showed total/incontrovertible remission of depression.” 75 Their depressive rating dropped from 32, with >17 indicating severe depression, to a depression-free score of 3. All without apparent adverse effects.  

POLYGALA TENUIFOLIA

  • Improves memory and combats forgetfulness
  • Supports neurotransmitters required for learning, memory, and mental health
  • Promotes growth of new neurons in the brain
  • Increases neuroplasticity and cognitive function
Polygala tenuifolia is one of the fundamental herbs used in traditional Chinese medicine, used to improve memory and combat forgetfulness with aging. There are several mechanisms through with Polygala tenuifolia may accomplish these goals:
  • Inhibiting the breakdown of acetylcholine, dopamine, serotonin, and noradrenaline, neurotransmitters required for learning new information, memory storage, and overall mental health. 76,77
  • Increasing the expression of brain derived neurotrophic factor (BDNF), which is fundamental for neuroplasticity and neurogenesis. 78
  • Promoting the growth of new neurons in the brain.79
Several studies have shown improved cognitive function and brain performance with polygala supplementation.

N-ACETYL-L-TYROSINE

  • Critical for stress management
  • Boosts cognition, alertness, and information processing
  • Improves memory and mental health
L-tyrosine is a conditionally essential amino acid that serves as the precursor molecule from which we create the catecholamines: dopamine, adrenaline, and noradrenaline. Your brain needs a steady supply of tyrosine to make the catecholamines and keep your mental health at its peak, 80,81 particularly if you are under a lot of stress. 82 Several clinical trials have shown that tyrosine supplementation boosts cognition, alertness, and memory in stressful and demanding situations in otherwise healthy adults.83,84

PINE BARK EXTRACT

  • Potent antioxidant and anti-inflammatory compound
  • Improves memory and focus
  • Boosts brain function
Enzogenol is a patented pine bark extract containing over 80% proanthocyanidins, which are potent antioxidant and anti-inflammatory compounds found naturally in many fruits and vegetables, but especially apples, grapes, red wine, blueberries, and chocolate. 85 In a double-blind, randomized controlled trial of older men, 5 weeks of supplementation with 980 mg/d of Enzogenol significantly improved working memory. 86 Daily supplementation has also been shown to improve cognitive function in those with traumatic brain injury after 6 weeks. 87 Other studies have also documented cognitive improvements following supplementation with Pycnogenol, a similar pine bark extract containing ~70% proanthocyanidins.
  • In healthy middle-aged adults, 150 mg per day of pine bark extract for 12 weeks reduced oxidative stress by 30% while improving cognitive performance and mood. 88
  • In older adults with high levels of oxidative stress, 100 mg per day of pine bark extract for one year reduced oxidative stress by 28% and improved cognitive function, attention, and memory. 89
  • In adults with mild cognitive impairment, 100 mg per day of pine bark extract for 8 weeks improved cognitive function by 18%.90

MAGNESIUM TAURATE

  • Over 300 enzymes require magnesium to function properly!
  • Required for optimal nerve transmission Protects against cell death
  • Prevents mitochondrial dysfunction
  • Prevents migraines Improves anxiety and depression
  • Slows development of and severity of Parkinson’s and Alzheimer’s Reduces risk of stroke
Magnesium is required for over 300 enzymes to function properly. 91 We need it for our muscles to contract, to regulate blood pressure, for proper insulin signaling, and for the synthesis of DNA and proteins. Within the brain and nervous system, magnesium is required for optimal nerve transmission and protection against excitotoxicity (excessive excitation leading to cell death). 92,93 Not all forms of magnesium are the same. You’ll find many types on the market, and the evidence is clear that magnesium taurate demonstrates a superior ability to enter into the brain and increase the brain’s magnesium status. One study compared the tissue distribution of magnesium 8 hours after taking equal amounts of magnesium citrate, malate, oxide, sulfate, and taurate. 94 It was shown that magnesium taurate increased brain magnesium concentrations 10–20% more than the other forms. A meta-analysis of 8 randomized controlled trials found that supplementing with magnesium reduced the frequency and intensity of migraines regardless of age, sex, or dose. 95 A systematic review of 18 studies found that magnesium supplementation could help reduce feelings of anxiety in susceptible individuals. 96 Dietary magnesium intake is associated with a lower risk for depression, 97 and supplementation with 500 mg of magnesium oxide or magnesium chloride reduces depressive symptoms in adults with mild to moderate depression. 98,99 Some case reports have even shown rapid recovery (less than 7 days) from major depression using 125–300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime.100

B3 VARIANTS (NMN, NR, NIACIN & NIACINAMIDE)

NAD+ has received a ton of attention in the last few years as possibly one of the most important compounds for anti-aging, disease prevention, prevention of DNA damage, and longevity. It also happens to be one of the most important compounds in regulating mitochondrial energy production. Several studies have now found that boosting levels of NAD+ can have profound anti-aging effects, and can even “make old rats young again” (to steal some of the media headlines). 168-170 This is where vitamin B3 (and versions of it, like niacin, niacinamide, nicotinamide riboside and nicotinamide mononucleotide) come in… They boost levels of NAD+. 171 While much focus is now on nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), the best available research indicates that these extremely expensive ingredients may not be significantly superior to plain old niacin and niacinamide (which are far cheaper, and easier to take in larger quantities). In fact, some research suggests that NR and NMN actually get broken down in the digestive tract into niacinamide anyway. 168 In other words, it likely does not make a whole lot of sense to spend exorbitant amounts of money on these fancy versions of niacin/niacinamide (NR or NMN) when they may actually be getting digested into niacinamide anyway before being absorbed into the bloodstream. It is, however, true that NAD+ is a critically important compound for promoting youthful mitochondrial function and energy production. All these B3 derivatives boost NAD+ levels significantly.