Margir þættir geta haft áhrif á kvíða og geðheilsu. AnxiaEase™ inniheldur einstaka blöndu af rannsökuðum innihaldsefnum sem sýnt hefur verið fram á að styðji við heilbrigt streitu- og stressviðbragð og virki náttúrulega hæfileika huga og líkama til að höndla stress og kvíða.
AnxiaEase™ nálgast vandamálið á breiðvirkan hátt með því að nota aðlögunarjurtir eins og Ashwaganda og Holy Basil, nauðsynleg næringarefni eins og B6 vítamín og magnesíum, ásamt slakandi jurtum eins og Lemon Balm, Lavander og Passion Flower, ásamt vel rannsökuðum góðgerlastofnum sem eru talin hafa jákvæð áhrif á geð.
Nýjustu rannsóknir varðandi kvíða og stress tengd vandamál hafa einblínt töluvert á þarma-heila ásinn (e. gut-brain axis) og getu ákveðinna gerlastofna til að hafa jákvæð áhrif á cýtókín virkni tauga og heilbrigð gildi af serótóníni sem er mjög mikilvægt hormón sem hefur áhrif á tilfinningaleg viðbrögð.
Innihaldslýsing:
Lemon balm (Melissa officinalis), Holy basil extract (Ocimum sanctum), Lavender (Lavandula officinalis), Ashwaganda root, stem and leaf extract (Withania somnifera), Passion flower extract (Passiflora incarnata), Phosphatidylserine Sharp-PS® (from sunflower), Vitamin B6 (Pyridoxal-5-phosphate), Magnesium (magnesium taurinate), CereBiome® Lactobacillus helveticus (Rossel®-52) Bifidobacterium longum (Rosell®-175)
Ráðlagður dagsskammtur:
2 hylki tvisvar á dag með mat.
Heimildir
Ashwagandha Extrac: Withania Somnifera:
1. Auddy B. et al. A standardized Withania somnifera extract reduces stress related parameters in chronically stressed humans – a double‐blind, randomized, placebo‐controlled study. JANA. 2008. Vol. II, No. I, pp. 50‐56.
2. Chandrasekhar K. et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine. 2012. 34(3), 255
3. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebocontrolled study. Medicine (Baltimore). 2019;98(37):e17186.
4. Raguraman, V. et al. Withania somnifera Root Extract Enhances Telomerase Activity in the Human HeLa Cell Line .Advances in Bioscience and Biotechnology. 2016. 7(04), 199.
Phosphatidylserine:
1. Baumeister et al. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neuroscience. 2008 Jun;11(3):103-10.
2. Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004 Jun;7(2):119-26.
3. Hellhammer J, Vogt D, Franz N, Freitas U, Rutenberg D. A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health Dis. 2014;13:121. Published 2014 Jul 31. doi:10.1186/1476-511X-13-121 (400 mg PS)
4. Moré MI, Freitas U, Rutenberg D. Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia. Adv Ther. 2014;31(12):1247-1262.
Holy Basil: Ocimum sanctum
1. Sampath S, Mahapatra SC, Padhi MM, Sharma R, Talwar A. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Indian J Physiol Pharmacol. 2015 Jan-Mar;59(1):69-77. PMID: 26571987.
2. Chatterjee M, Verma P, Maurya R, Palit G. Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression. Pharm Biol. 2011 May;49(5):477-83.
3. Bhattacharyya D, Sur TK, Jana U, Debnath PK. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008 Sep;10(3):176-9. PMID: 19253862.
4. Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med. 2017;2017:9217567.
Lemon Balm: Melissa Officinalis
1. Haybar H et al. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clin Nutr ESPEN. 2018 Aug;26:47-52.
2. Cases J et al. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011;4(3):211-218.
3. Ranjbar M et al. Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial. Integr Med Res. 2018;7(4):328-332.
Magnesium:
1. N. Uysal et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res 187, 128-136 (2019)
Lavander:
1. Kasper S, Müller WE, Volz HP, Möller HJ, Koch E, Dienel A. Silexan in anxiety disorders: Clinical data and pharmacological background. World J Biol Psychiatry. 2018 Sep;19(6):412-420.
2. Woelk H, Schläfke S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010 Feb;17(2):94-9.
Probiotics:
1. Zhang X et al. Effects of Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota on Constipation in Patients with Depression: A Randomized, DoubleBlind, Placebo-Controlled Trial. Nutrients. 2021 Jun 29;13(7):2238.
2. Steenbergen L. et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain, Behavior and Immunity. 2015. 258-264.
3. Morkl S. et al. Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry. Current Nutrition Reports (2020) 9:171–182.
4. Pinto-Sanchez MI et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017 Aug;153(2):448-459.
5. A. Kazemi et al. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin Nutr. 2019 Apr;38(2):522-528
6. M. Messaoudi et al. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes Jul-Aug 2011;2(4):256-61
Passionflower: Passiflora incarnata
1. Akhondzadeh S et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct;26(5):363-7.
2. Janda K et al. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients. 2020;12(12):3894. 3. da Fonseca LR et al. Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential. Scientific World Journal. 2020.
