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GlycanAge|Heilsuástandsmæling|Hversu gamall er líkaminn þinn?

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Framleiðandi: GlycanAge

GlycanAge heilsuástandsmælingin mælir bólgur á sameindastigi sem er vísir að núverandi heilsuástandi þínu og getur spáð fyrir um hvernig heilsan þín þróast. 

Mælingin gefur upp ástand ónæmiskerfisins og bólguástand líkamans.

Eftir að hafa rannsakað um 80 þúsund einstaklinga á yfir 20 árum hafa vísindamenn komist að því að hægt er að greina líffræðilegan aldur með því að skoða glýkana (e. glycans) og hvernig lífstílsbreytingar geta haft áhrif á aldurinn á tiltölulega skömmum tíma. Fjöldinn allur af ritrýndum vísindagreinum hefur verið birtur um glýkana og má sjá brot af þeim hér fyrir neðan í heimildunum og eru linkar á greinarnar þar.

 

Hvað eru glýkanar?

Glýkanar (e. glycans) eru sykursameindir sem umlykja og breyta prótínum í líkamanum þínum. Þeir bregðast við lífstílsbreytingum og gefa til kynna ástand ónæmiskerfis þíns eins og áður hefur komið fram sem ákvarðar líffræðilegan aldur þinn.

Hvernig veistu að lífstílsbreytingar þínar eða mataræðisbreytingar eru að skila tilætluðum árangri eða hvort þær henta þér og þínum líkama?

GlycanAge er fyrsta prófið sem selt er til einstaklinga og gefur þér niðurstöður með líffræðilegum aldri þínum. Það er eina mælingin sem sannað hefur verið að hægt sé að mæla skammtíma lífstílsbreytingar og hvernig þær hafa áhrif á bólgur og líffræðilegan aldur. 

Ítarleg greining er gerð á glýkönunum þínum, þú færð uppgefinn líffræðilegan aldur og gefin eru gildi á "Glycan Mature" sem eru slæmir (bólguhvetjandi) glýkanar, "Glycan Health" sem eru góðir glýkanar (bólguhamlandi) og síðan "Glycan Youth" sem einnig eru góðir glýkanar. Þessi gildi eru gefin upp og þau borin saman við annað fólk á þínum aldurshópi.

Hvernig virkar þetta próf?

1. Þú pantar próf á Heilsubarnum og færð sent eins og aðrar vörur. 

2. Hérna er vídeó sem þú getur skoðað.

Í grófum dráttum þá:

- Hitarðu hendurnar aðeins með því að nudda þeim saman.

- Sótthreinsarðu svæði á puttanum sem þú ætlar að stinga í. 

- Þrýstir plaststykki að húð og lítil ná skýst í fingur (eins og í blósykursmælingu)

- Setur nokkra blóðdropa á pappa sem fylgir með. 

- Setur plástur á fingur.

- Pakkar inn eftir leiðbeiningum

3. Lætur Heilsubarinn vita að þú sért að fara að skila inn mælingu og ferð með hana í Even Labs, Faxafeni 14. 

4. Heilsubarinn póstleggur hana og pakkinn brunar til GlycanAge þar sem hann fer beint á tilraunastofu og er blóðið greint þar. 

- Eftir um 4-6 vikur koma niðurstöður á reikninginn þinn sem þú getur skoðað og í kjölfarið býðst þér að fá ítarlega ráðgjöf frá GlycanAge, ráðleggingar og yfirferð á niðurstöðunum. 

 

Heimildir:

1. Immunoglobulin G glycome composition in transition from premenopause to postmenopause

2. Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity

3. A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation

4.  A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

5. Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India

6. Investigation of the causal relationships between human IgG N-glycosylation and 12 common diseases associated with changes in the IgG N-glycome

7. Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism

8. Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology

9. Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

10. Extensive weight loss reduces glycan age by altering IgG N-glycosylation

11. A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection

12. N-glycosylation of immunoglobulin G predicts incident hypertension

13. Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional
Effectors in Aging and Diseases

14. Immunoglobulin G glycome composition in transition from pre-menopause to menopause

15. Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

16. Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

17. Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

18. Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder

19. Effects of estradiol on biological age measured using the glycan age index

20. Biomarkers of biological age as predictors of COVID-19 disease severity

21. Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study

 22. Global variability of the human IgG glycome

23. Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population

24. N-Glycan Analysis by Ultra-Performance Liquid Chromatography and Capillary Gel Electrophoresis with Fluorescent Labeling

25. Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension

26. Association of the IgG N-glycome with the course of kidney function in type 2 diabetes

27. Inflammatory bowel disease - glycomics perspective

28. Translational glycobiology: from bench to bedside

29. Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

30. Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

31. Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes

32. Type 2 Diabetes Mellitus is Associated with the Immunoglobulin G N-Glycome through Putative Proinflammatory Mechanisms in an Australian Population

33. Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile

34. Next-Generation (Glycomic) Biomarkers for Cardiometabolic Health: A Community-Based Study of Immunoglobulin G N-Glycans in a Chinese Han Population

35. Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis

36. N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease

37. Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

38. The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

39. Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy

40. Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

41. Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

42. Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease

43. Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

44. The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

45. Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts

46. Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

47. The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins

48. IgG glycan patterns are associated with type 2 diabetes in independent European populations

49. IgG glycosylation and DNA methylation are interconnected with smoking

50. Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

51. Immunoglobulin G glycosylation in aging and diseases

52. Ubiquitous Importance of Protein Glycosylation

53. The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease

54. Connecting genetic risk to disease end points through the human blood plasma proteome

55. Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

56. Effects of statins on the immunoglobulin G glycome

57. Estrogens regulate glycosylation of IgG in women and men

58. Immunoglobulin G N-Glycans as Potential Postgenomic Biomarkers for Hypertension in the Kazakh Population

 

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