ProbioMed 50 meltingargerlar

1. Petersen ER, Claesson MH, Wedebye Schmidt EG, et al. Consumption of probiotics increases the effect of regulatory T cells in transfer colitis. Inflamm Bowel Dis. 2012;18(11):131‑142. doi:10.1002/ibd.21709

2. Zeuthen LH, Fink LN, Metzdorff SB, et al. Lactobacillus acidophilus induces a slow but more sustained chemokine and cytokine response in naïve foetal enterocytes compared to commensal Escherichia coli. BMC Immunol. 2010;11:2. doi.org/10.1186/1471‑2172‑11‑2

3. Chen CC, Chiu CH, Lin TY, Shi HN, Walker WA. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res. 2009;65(2):169‑175. doi:10.1203/PDR.0b013e31818d5a06

4. Elawadli I, Brisbin JT, Mallard BA, et al. Differential effects of lactobacilli on activation and maturation of mouse dendritic cells. Benef Microbes. 2014;5(3):323‑334. doi:10.3920/BM2013.0066

5. Paineau D, Carcano D, Leyer G, et al. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double‑blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 2008;53:107‑113. doi:10.1111/j.1574695X.2008.00413.x

6. Bertuccini L, Russo R, Iosi F, Superti F. Effects of Lactobacillus rhamnosus and Lactobacillus acidophilus on bacterial vaginal pathogens. Intl J Immunopathol Pharmacol. 2017;30(2):163‑167. doi:10.1177/0394632017697987

7. Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: a randomized controlled trial. J Dig Dis. 2019;20(9):435‑446. doi:10.1111/17512980.12797

8. Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza‑like symptom incidence and duration in children. Pediatrics. 2009;124:e172‑e179. doi:10.1542/peds.20082666

9. Saber R, Zadeh M, Pakanati KC, Bere P, Klaenhammer T, Mohamadzadeh M. Lipoteichoic acid‑deficient Lactobacillus acidophilus regulates downstream signals. Immunotherapy. 2011;3(3):337‑347. doi.org/10.2217/imt.10.119

10. Björklund M, Ouwehand AC, Forssten SD, et al. Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol. Age (Dordr). 2011;34(4):987‑999. doi:10.1007/s11357‑011‑9294‑5

11. Engelbrektson A, Korzeniki JR, Pittler A, et al. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol. 2009;58:663‑670. doi:10.1099/jmm.0.476150

12. Waitzberg DL, Logullo LC, Bittencourt AF, et al. Effect of synbiotic in constipated adult women – a randomized, double‑blind, placebo‑controlled study of clinical response. Clin Nutr. 2013;32(1):27‑33. doi:10.1016/j.clnu.2012.08.010

13. Ouwehand AC, Tiihonen K, Saarinen M, Putaala H, Rautonen N. Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters. Br J Nutr. 2009;101:367‑375. doi:10.1017/S0007114508003097

14. Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double‑blind, placebo‑controlled, clinical trial. Am J Clin Dermatol. 2010;11(5):351‑361. doi:10.2165/11531420‑000000000‑00000

15. West NP, Hughes L, Ramsey R, et al. Probiotics, anticipation stress, and the acute immune response to night shift. Front Immunol. 2021;11:599547. doi:10.3389/fimmu.2020.599547

16. Polewski MA, Krueger CG, Reed JD, Leyer G. Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra‑intestinal pathogenic E. coli. J Funct Foods. 2016;25:123‑134. doi:10.1016/j.jff.2016.05.015

17. Lönnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol. 2010;44(2):106‑112. doi:10.1097/mcg.0b013e3181b2683f

18. Nobaek S, Johansson ML, Göran M, Ahrné S, Jeppsson B. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol. 2000;95(5):1231‑1238. doi:10.1111/j.1572‑0241.2000.02015.x

19. Foligne B, Nutten S, Grangette C, et al. Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria. World J Gastroenterol. 2007;13(2):236‑243. doi:10.3748/wjg.v13.i2.236

20. Vemuri R, Shinde T, Shastri MD, et al. A human origin strain Lactobacillus acidophilus DDS‑1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics. Int J Med Sci. 2018;15(9):840‑848. doi:10.7150/ijms.25004

21. Bosch M, Méndez M, Pérez M, Farran A, Fuentes MC, Cuñé J. Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly. Nutr Hosp. 2012;27(2):504‑509. doi:10.1590/S0212‑16112012000200023

22. Ouwehand AC, Nermes M, Collado MC, Rautonen N, Salminen S, Isolauri E. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterol. 2009;15(26):3261‑3268. doi:10.3748/wjg.15.3261

23. Gopal PK, Prasad J, Gill HS Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto‑oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutr Res. 2003;23:1313‑1328. doi.org/10.1016/S0271‑5317(03)00134‑9

24. Prasad J, Sazawal S, Dhingra U, Gopal PK. Detection of viable Bifidobacterium lactis HN019 (DR10TM) in stools of children during a synbiotic dietary intervention trial. Intl Dairy J. 2013;30:64‑67. doi.org/10.1016/j.idairyj.2012.12.001

25. Wickens K, Black PN, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double‑blind, randomized, placebo‑controlled trial. J Allergy Clin Immunol. 2008;122:788‑794. doi.org/10.1016/jaci.2008.07.011

26. Dalziel JE, Anderson RC, Peters JS, et al. Promotility action of the probiotic Bifidobacterium lactis HN019 extract compared with prucalopride in isolated rat large intestine. Front Neurosci. 2017;11:20. doi:10.3389/fnins.2017.00020

27. Ibarra A, Latreille‑Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28‑day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: a double‑blind, randomized, placebo‑controlled and dose‑ranging trial. Gut Microbes. 2018;9(3):236‑251. doi:10.1080/19490976.2017.1412908

28. Waller PA, Gopal PK, Leyer GJ, et al. Dose‑response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J Gastroenterol. 2011;46:1057‑1064. doi:10.3109/00365521.2011.584895

29. Miller LE, Lehtoranta L, Lehtinen MJ. The effect of Bifidobacterium animalis ssp. lactis HN019 on cellular immune function in healthy elderly subjects: systematic review and meta‑analysis. Nutrients. 2017;9:191. doi:10.3390/nu9030191

30. Rizzardini G, Eskesen D, Calder PC, Capetti A, Jespersen L, Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double‑blind, placebo‑controlled study. Br J Nutr. 2012;107(6):876‑884. doi:10.1017/S000711451100420X

31. Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010;103(1):58‑68. doi:10.1017/S0007114509991395

32. Alipour B, Homayouni‑Rad Z, Vaghef‑Mehrabany E, et al. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double‑blind clinical trial. Int J Rheum Dis. 2014;17(5):519‑527. doi:10.1111/1756185X.12333

33. Endo H, Higurashi T, Hosono K, et al. Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low‑dose aspirin users: a pilot randomized controlled study. J Gastroenterol. 2011;46(7):894‑905. doi:10.1007/s00535‑011‑0410‑1

34. D’Incà R, Barollo M, Scarpa M, et al. Rectal administration of Lactobacillus casei DG modifies flora composition and Toll‑like receptor expression in colonic mucosa of patients with mild ulcerative colitis. Dig Dis Sci. 2011;56(4):1178‑1187. doi:10.1007/s10620‑010‑1384‑1

35. Duque Braga T, Alves Pontes da Silva G, Cabral de Lira PI, de Carvalho Lima M. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very‑low‑birth‑weight preterm infants: a double‑blind, randomized, controlled trial. Am J Clin Nutr. 2011;93(1):81‑86. doi:10.3945/ajcn.2010.29799

36. Hulston CJ, Churnside AA, Venables MC. Probiotic supplementation prevents high‑fat, overfeeding‑induced insulin resistance in human subjects. Br J Nutr. 2015;113(4):596‑602. doi:10.1017/S0007114514004097

37. Ishikawa H, Matsumoto S, Ohashi Y, et al. Beneficial effects of probiotic bifidobacterium and galacto‑oligosaccharide in patients with ulcerative colitis: a randomized controlled study. Digestion. 2011;84(2):128‑133. doi:10.1159/000322977

38. Del Piano M, Carmagnola S, Anderloni A, et al. The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double‑blind, randomized, placebo‑controlled study. J Clin Gastroenterol. 2010;44(suppl 1):S30‑S34. doi:10.1097/MCG.0b013e3181ee31c3

39. Asemi Z, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A. Effect of multispecies probiotic supplements on metabolic profiles, hs‑CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab. 2013;63(12):1‑9. doi:10.1159/000349922

40. Håkansson Å, Andrén Aronsson C, Brundin C, Oscarsson E, Molin G, Agardh D. Effects of Lactobacillus plantarum and Lactobacillus paracasei on the peripheral immune response in children with celiac disease autoimmunity: a randomized, double‑blind, placebo‑controlled clinical trial. Nutrients. 2019;11(8):1925. doi:10.3390/nu11081925

41. Kim WK, Jang YJ, Han DH, et al. Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota. Gut Microbes. 2020;12(1):1819156. doi:10.1080/19490976.2020.1819156

42. Chen CL, Hsu PY, Pan TM. Therapeutic effects of Lactobacillus paracasei subsp. paracasei NTU 101 powder on dextran sulfate sodium‑induced colitis in mice. J Food Drug Anal. 2019;27(1):83‑92. doi:10.1016/j.jfda.2018.05.004

43. Pan T, Guo HY, Zhang H, Liu AP, Wang XX, Ren FZ. Oral administration of Lactobacillus paracasei alleviates clinical symptoms of colitis induced by dextran sulphate sodium salt in BALB/c mice. Benef Microbes. 2014;5(3):315‑322. doi:10.3920/BM2013.0041

44. Lewis ED, Antony JM, Crowley DC, et al. Efficacy of Lactobacillus paracasei HA‑196 and Bifidobacterium longum R0175 in alleviating symptoms of irritable bowel syndrome (IBS): a randomized, placebo‑controlled study. Nutrients. 2020;12(4):1159. doi:10.3390/nu12041159

45. Neville BA, O’Toole PW. Probiotic properties of Lactobacillus salivarius and closely related Lactobacillus species. Future Microbiol. 2010;5(5):759‑774. doi:10.2217/fmb.10.35

46. Iwamoto T, Suzuki N, Tanabe K, Takeshita T, Hirofuji T. Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open‑label pilot trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):201‑208. doi:10.1016/j.tripleo.2010.03.032

47. Nishihara T, Suzuki N, Yoneda M, Hirofuji T. Effects of Lactobacillus salivarius‑containing tablets on caries risk factors: a randomized open‑label clinical trial. BMC Oral Health. 2014;14:110. doi:10.1186/1472‑6831‑14‑110

48. Capurso L. Thirty years of Lactobacillus rhamnosus GG: a review. J Clin Gastroenterol. 2019;53(Suppl1):S1‑S41. doi:10.1097/MCG.0000000000001170

49. Szajewska H, Kołodziej M. Systematic review with meta‑analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic‑associated diarrhoea in children and adults. Aliment Pharmacol Ther. 2015;42(10):1149‑1157. doi:10.1111/apt.13404

50. Li YT, Xu H, Ye JZ, et al. Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: a systematic review with meta‑analysis. World J Gastroenterol. 2019;25(33):4999‑5016. doi:10.3748/wjg.v25.i33.4999

51. Szajewska H, Kołodziej M, Gieruszczak‑Białek D, Skórka A, Ruszczyński M, Shamir R. Systematic review with meta‑analysis: Lactobacillus rhamnosus GG for treating acute gastroenteritis in children — a 2019 update. Aliment Pharmacol Ther. 2019;49(11):1376‑1384. doi:10.1111/apt.15267

52. Pedersen N, Andersen NN, Végh Z, et al. Ehealth: low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome. World J Gastroenterol. 2014;20(43):16215‑16226. doi:10.3748/wjg.v20.i43.16215

53. Liu S, Hu P, Du X, Zhou T, Pei X. Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: a meta‑analysis of randomized, placebo‑controlled trials. Indian Pediatr. 2013;50(4):377‑381. doi:10.1007/s13312‑013‑0123‑z

54. Horvath A, Dziechciarz P, Szajewska H. Meta‑analysis: Lactobacillus rhamnosus GG for abdominal pain‑related functional gastrointestinal disorders in childhood. Aliment Pharmacol Ther. 2011;33(12):1302‑1310. doi:10.1111/j.13652036.2011.04665.x

55. Miki K, Urita Y, Ishikawa F, et al. Effect of Bifidobacterium bifidum fermented milk on Helicobacter pylori and serum pepsinogen levels in humans. J Dairy Sci. 2007;90(6):2630‑2640. doi:10.3168/jds.2006‑803

56. Olivares M, Castillejo G, Varea V, Sanz Y. Double‑blind, randomised, placebo‑controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. Br J Nutr. 2014;112(1):30‑40. doi:10.1017/S0007114514000609

57. Macfarlane S, Cleary S, Bahrami B, Reynolds N, Macfarlane GT. Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double‑blind, placebo‑controlled crossover study. Aliment Pharmacol Ther. 2013;38(7):804‑816. doi:10.1111/apt.12453

58. Malaguarnera M, Vacante M, Antic T, et al. Bifidobacterium longum with fructo‑oligosaccharides in patients with non alcoholic steatohepatitis. Dig Dis Sci. 2012;57(2):545‑553. doi:10.1007/s10620‑011‑1887‑4